[{"data":1,"prerenderedAt":1031},["ShallowReactive",2],{"$fcLUVhxztktrZK1KT9Z6bP0n29b6hV0GevRQdAmXtsn8":3,"localizations-yahy2fbzr1uk158d0yvm5xlv-en":292,"global-seo-setting":297,"header-setting":344,"footer":412,"certificates":546,"navigations":693,"localizations-pages-yahy2fbzr1uk158d0yvm5xlv-en":1026},{"data":4,"meta":291},{"id":5,"title":6,"slug":7,"createdAt":8,"updatedAt":9,"publishedAt":10,"documentId":11,"locale":12,"showOnArticlesPage":13,"disablePrerender":14,"prerenderTranslation":15,"category":16,"tagCategory":15,"blogImage":15,"settings":15,"seo":24,"body":28},3004,"Cluster - humidity mapping","humidity-mapping","2026-06-02T11:45:29.048Z","2026-06-08T06:44:54.318Z","2026-06-08T06:44:54.780Z","yahy2fbzr1uk158d0yvm5xlv","en",true,false,null,{"id":17,"name":18,"slug":19,"createdAt":20,"updatedAt":21,"publishedAt":22,"documentId":23,"locale":12},1,"Temperature mapping","temperature-mapping","2023-11-21T11:15:18.553Z","2024-01-22T08:55:42.878Z","2023-11-21T11:15:21.494Z","pwyjqghevtcklhb35py7i7lq",{"id":25,"pageTitle":26,"shortDescription":27,"noIndex":14,"noAI":14,"noFollow":14,"Schema":15,"canonicalURL":15,"ogTitle":15,"ogDescription":15,"noSitemap":14,"schemaType":15,"image":15},3950,"Humidity mapping in pharma: requirements and protocol | Eupry","When is humidity mapping required, how does it differ from temperature mapping, and how do you run a compliant study? A practical GxP guide.",[29,130,159,166,171,203,209,214,247,276,282,287],{"__component":30,"id":31,"title":32,"content":33,"blockId":15,"ulStyle":15,"video":15,"auto play":14,"imageLeftTextRight":14,"preTitle":15,"preTitleColor":15,"ctaInfoText":34,"titleLevel":35,"imageUrl":15,"subTitle":15,"verticalCenteredText":14,"hideOnMobile":14,"hideTopDecoration":14,"hideLastUpdated":14,"buttons":36,"media":44,"employee":72},"blocks.media-and-text-split-view",14250,"Humidity mapping: Requirements, protocol, and sensor placement","Temperature mapping is standard practice. Humidity mapping decides whether you monitor humidity at all, and the FDA has cited facilities for monitoring temperature but not humidity on humidity-sensitive products.","A GxP protocol with everything you need to conduct a compliant mapping study.","h1",[37],{"id":38,"title":39,"href":40,"type":41,"size":42,"arrow":43,"blockId":15,"fullWidth":13,"quizId":15,"icon":15,"lucideIcon":15,"ariaLabel":15},13811,"Download a temperature and humidity mapping protocol","#form","hot-pink-dark","default","down",{"id":45,"name":46,"alternativeText":47,"caption":15,"width":48,"height":49,"formats":50,"hash":63,"ext":52,"mime":55,"size":64,"url":65,"previewUrl":15,"provider":66,"provider_metadata":67,"createdAt":68,"updatedAt":69,"documentId":70,"publishedAt":71,"focalPoint":15},2123,"Humidity and temperature mapping.png","Isometric thermometer showing low temperature with teal mercury and water droplets on blue-purple gradient 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co-founder","","https:\u002F\u002Fwww.linkedin.com\u002Fin\u002Fadam-hartmann-kruckow-63672831\u002F","2023-11-13T09:44:15.601Z","2026-06-17T10:12:53.777Z","2026-06-17T10:13:21.543Z","mtcps4rkmkjzs82xstm7oqit","\u002Fabout-us\u002Fadam-hartmann-kruckow\u002F",{"id":84,"name":85,"alternativeText":86,"caption":15,"width":87,"height":88,"formats":89,"hash":100,"ext":91,"mime":94,"size":101,"url":102,"previewUrl":15,"provider":66,"provider_metadata":103,"createdAt":104,"updatedAt":105,"documentId":106,"publishedAt":107,"focalPoint":15},638,"2021.12.16_adam1-scaled.jpg","Smiling man in dark suit and burgundy tie against light background, professional 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co-fondateur","2026-08-27T09:17:25.841Z","2026-08-27T09:17:25.944Z","fr",{"id":116,"name":74,"workTitle":117,"testimonial":118,"email":15,"linkedIn":77,"createdAt":119,"updatedAt":120,"publishedAt":121,"documentId":81,"locale":122,"url":82},317,"CCO & Mitgründer","After my internship in Eupry, I started working full-time as a Key Account Manager.\n\nEupry has not only introduced me to new friends but has developed me as a human and taught me valuable lessons and skills about responsibility, teamwork, and building up a well-working sales department.","2026-05-28T14:25:01.246Z","2026-08-17T11:41:18.018Z","2026-08-17T11:41:18.314Z","de",{"id":124,"name":74,"workTitle":125,"testimonial":76,"email":15,"linkedIn":77,"createdAt":126,"updatedAt":127,"publishedAt":128,"documentId":81,"locale":129,"url":82},318,"CCO e co-fondatore","2026-08-03T14:45:01.363Z","2026-08-17T11:41:19.190Z","2026-08-17T11:41:19.446Z","it",{"__component":131,"id":132,"title":133,"description":15,"blockId":15,"imageUrl":15,"layout":15,"hideOnMobile":14,"items":134,"media":15},"blocks.table-of-contents",232,"On this page",[135,139,143,147,151,155],{"id":136,"label":137,"link":138},1439,"What is humidity mapping?","#what",{"id":140,"label":141,"link":142},1440,"When is humidity mapping required?","#when",{"id":144,"label":145,"link":146},1441,"How is humidity mapping different from temperature mapping?","#how",{"id":148,"label":149,"link":150},1442,"How do you run a humidity mapping study?","#how2",{"id":152,"label":153,"link":154},1443,"Can continuous monitoring and mapping reduce humidity re-mapping?","#can",{"id":156,"label":157,"link":158},1444,"Frequently asked questions about humidity mapping","#faq",{"__component":160,"id":161,"text":162,"columns":163,"title":137,"blockId":164,"hideOnMobile":14,"ulStyle":15,"ulColor":15,"withBackground":15,"buttons":165},"blocks.text",4115,"Humidity mapping is a point-in-time qualification study that documents how relative humidity is distributed across a defined space – a stability chamber, cleanroom, warehouse, or cold room. It identifies the high and low humidity zones the way temperature mapping identifies hot and cold spots, so you can place ongoing monitoring sensors where they actually represent risk.\n\nThis sits inside the recognized definition of mapping. WHO guidance describes mapping as the documented measurement of temperature and relative humidity distribution within a storage area, and lists humidity-distribution uniformity as a mapping objective. The study answers one question for an auditor: Does relative humidity stay within its defined limits everywhere the product is stored or processed, not just where a sensor happens to sit?\n\n### Humidity mapping vs. humidity monitoring\n\nThese are two stages of the same lifecycle, and conflating them is a common documentation gap. Mapping qualifies the space once, under defined conditions. Monitoring watches it continuously afterward, at the fixed points, the mapping study justified.\n\nMapping tells you where to monitor. Monitoring tells you whether the space still behaves the way the mapping study said it would. Learn more about humidity monitoring and see the difference between humidity mapping and ongoing monitoring [in the monitoring guide](\u002Ftemperature-monitoring\u002Fhumidity-monitoring-pharma\u002F).","one","what",[],{"__component":160,"id":167,"text":168,"columns":163,"title":141,"blockId":169,"hideOnMobile":14,"ulStyle":15,"ulColor":15,"withBackground":15,"buttons":170},4116,"Humidity mapping is less universally required than temperature mapping, and overclaiming it as mandatory damages credibility with quality teams. The honest position: it is required where relative humidity is a defined critical parameter, and the situations where that applies are growing.\n\nIt clearly applies in these cases:\n\n**Stability chambers:** ICH stability conditions are defined in both temperature and relative humidity – for example 25°C\u002F77°F at 60% RH for long-term and 40°C\u002F104°F at 75% RH for accelerated testing. A chamber holding those conditions has to demonstrate humidity distribution, not just temperature.\n\n**Moisture-sensitive products:** Where product stability data sets a relative humidity limit, the spaces holding that product inherit the parameter.\n\n**Cleanrooms and controlled areas:** Where relative humidity is specified for process control, contamination prevention, or material handling.\n\nOn the regulatory side, no authority issues a blanket humidity mapping mandate, which is exactly why the requirement gets missed. The FDA does not name humidity mapping. It expects humidity control where appropriate under 21 CFR 211.46(b), and it enforces the parameter gap on the monitoring side – facilities have been cited for monitoring temperature but not humidity on humidity-sensitive products. EU GMP Annex 15 frames qualification around critical parameters under a risk-based approach. USP \u003C1079.4>, official since 2024, is written for temperature mapping, but its qualification principles extend to mapping relative humidity in spaces such as stability chambers.\n\nThe practical chain: if humidity is a critical parameter, you are expected to monitor it. Mapping is what tells you whether the space holds humidity uniformly and where the monitoring sensors belong. Skip the mapping, and the monitoring program has no documented basis – and that absence is what an inspector finds.\n\n**Also read**: [Pharmaceutical temperature mapping guidelines](\u002Ftemperature-mapping\u002Fguidelines-pharmaceutical\u002F)","when",[],{"__component":172,"id":173,"title":174,"lead":175,"hubspotFormId":176,"blockId":177,"hubspotMeetingUrl":15,"titleLevel":178,"preTitle":179,"preTitleColor":180,"imageUrl":15,"hideOnMobile":14,"media":181},"blocks.download-form",3380,"Temperature and humidity mapping protocol template","A GxP-ready protocol structure for qualifying both parameters in one study, with acceptance criteria, sensor planning, and reporting built in.","eeac4fad-5689-4cdf-8b61-7482fba5a801","form","h2","Download","Brain Freeze Dark",{"id":182,"name":183,"alternativeText":184,"caption":15,"width":185,"height":186,"formats":187,"hash":196,"ext":52,"mime":55,"size":197,"url":198,"previewUrl":15,"provider":66,"provider_metadata":199,"createdAt":200,"updatedAt":201,"documentId":202,"publishedAt":200,"focalPoint":15},2124,"HVHV44.png","Eupry temperature and humidity mapping protocol template document pages with tables and cyan branding",1026,1044,{"thumbnail":188},{"ext":52,"url":189,"hash":190,"mime":55,"name":191,"path":15,"size":192,"width":193,"height":59,"sizeInBytes":194,"provider_metadata":195},"https:\u002F\u002Fres.cloudinary.com\u002Feupry\u002Fimage\u002Fupload\u002Fv1780403217\u002Fthumbnail_HVHV_44_81a2e4c924.png","thumbnail_HVHV_44_81a2e4c924","thumbnail_HVHV44.png",23.73,153,23728,{"public_id":190,"resource_type":62},"HVHV_44_81a2e4c924",728.66,"https:\u002F\u002Fres.cloudinary.com\u002Feupry\u002Fimage\u002Fupload\u002Fv1780403218\u002FHVHV_44_81a2e4c924.png",{"public_id":196,"resource_type":62},"2026-06-02T12:26:59.123Z","2026-06-02T22:01:18.068Z","u4zttwhr559x2tpt6kdr615r",{"__component":204,"id":205,"title":145,"content":206,"video":15,"blockId":207,"ulStyle":15,"preTitle":15,"preTitleColor":15,"titleLevel":178,"imageUrl":15,"subTitle":15,"videoAutoplay":13,"hideOnMobile":14,"ctaInfoText":15,"hideLastUpdated":14,"buttons":208,"media":15,"employee":15},"blocks.media-and-text",3867,"The study design rhymes with temperature mapping, but three differences change how you run it.\n\n**Relative humidity depends on temperature.** The same amount of moisture in the air reads as different relative humidity at different temperatures. Humidity data cannot be interpreted in isolation – it has to be read alongside the temperature at the same point and time, which is why combined sensors are the practical norm.\n\n**Humidity sensors equilibrate more slowly.** Relative humidity sensors take longer to stabilize than temperature sensors after a change in conditions. Studies need adequate stabilization time built in, and rushing it produces data that looks noisier than the space actually is.\n\n**Humidity is more exposed to outside conditions.** Door openings, HVAC cycles, and seasonal outdoor humidity move relative humidity more sharply than they move temperature. That makes worst-case timing and seasonal coverage more consequential for humidity than for temperature.\n\n**Also see**: [Temperature mapping: Tips, frameworks, and pitfalls](\u002Ftemperature-mapping)","how",[],{"__component":160,"id":210,"text":211,"columns":163,"title":149,"blockId":212,"hideOnMobile":14,"ulStyle":15,"ulColor":15,"withBackground":15,"buttons":213},4117,"A humidity mapping study follows the same protocol backbone as any mapping study: defined scope, risk assessment, calibrated equipment, justified sensor placement, a stated test period, and acceptance criteria tied to the report. If you are building the document from scratch, the structure is the same one covered in the [temperature mapping protocol guide](\u002Ftemperature-mapping\u002Fprotocol\u002F). Humidity mapping is typically run at initial qualification as part of OQ\u002FPQ, after significant HVAC changes, after a layout change that could affect airflow or moisture distribution, and periodically based on risk assessment – most often where humidity limits are tight.\n\n### Sensor placement and how many sensors\n\nPlacement follows the same risk-based logic as temperature mapping – a distribution that covers the full volume, with extra attention to likely humidity sources and sinks: doors, HVAC supply and return, exterior walls, and areas of poor air circulation. There is no fixed sensor count. It scales with volume, layout complexity, and the number of distinct zones, justified in the risk assessment. USP \u003C1079.4> also suggests carrying 5 to 10 percent spare calibrated monitors in case of failure during the study. Combined [temperature and humidity data loggers](\u002Fdata-logger\u002F) record both parameters at each position, so you are not running two separate sensor grids.\n\n### Study duration and seasonal considerations\n\nDuration follows the same guidance as temperature mapping: commonly 24 to 72 hours for chambers and temperature-controlled equipment, and 7 to 10 days for warehouses, logged at 5 to 15-minute intervals. Because relative humidity is so sensitive to outdoor conditions, seasonal coverage matters more than it does for temperature – the worst-case humidity season is rarely the worst-case temperature season.\n\n**Also read**: [A practical guide to summer mapping in GxP](\u002Ftemperature-mapping\u002Fsummer-mapping\u002F)\n\n### Acceptance criteria and reporting\n\nAcceptance criteria come from the defined storage condition or from product stability data – not from a generic limit. The report documents minimum, maximum, and mean relative humidity per position, read against temperature, identifies the humidity extremes, and records any deviations against the criteria. The mechanics of working through the dataset are the same as for temperature, covered in [how to analyze data from a mapping exercise](\u002Ftemperature-mapping\u002Fanalyze-data-from-mapping-exercise\u002F).","how2",[],{"__component":30,"id":215,"title":153,"content":216,"blockId":154,"ulStyle":15,"video":15,"auto play":14,"imageLeftTextRight":14,"preTitle":15,"preTitleColor":15,"ctaInfoText":15,"titleLevel":178,"imageUrl":15,"subTitle":15,"verticalCenteredText":13,"hideOnMobile":14,"hideTopDecoration":14,"hideLastUpdated":14,"buttons":217,"media":224,"employee":15},14251,"Ordinary continuous monitoring does not replace mapping. Monitoring watches a fixed set of points. It does not re-qualify how relative humidity is distributed across the whole space, which is what a re-mapping study does. The two are not interchangeable.\n\n[Continuous monitoring and mapping](\u002Ftemperature-mapping\u002Fcontinuous-temperature-mapping\u002F) is a different approach. Where sensor coverage and data density are sufficient, the ongoing record can serve as standing evidence of humidity distribution, which may reduce the need for periodic re-mapping studies – provided the data demonstrates consistent performance and is supported by a documented rationale, an auditor can follow. This is an emerging practice rather than a settled regulatory standard, so the rationale carries as much weight as the data.",[218],{"id":219,"title":220,"href":221,"type":222,"size":42,"arrow":223,"blockId":15,"fullWidth":14,"quizId":15,"icon":15,"lucideIcon":15,"ariaLabel":15},13812,"How continuous monitoring and mapping works","\u002Fsolutions\u002Fcontinuous-mapping\u002F","black","right",{"id":225,"name":226,"alternativeText":227,"caption":15,"width":228,"height":229,"formats":230,"hash":239,"ext":91,"mime":94,"size":240,"url":241,"previewUrl":15,"provider":66,"provider_metadata":242,"createdAt":243,"updatedAt":244,"documentId":245,"publishedAt":246,"focalPoint":15},1205,"Question mark.jpg","3D isometric white question mark icon with dark shadow on a light blue gradient background",1200,903,{"thumbnail":231},{"ext":91,"url":232,"hash":233,"mime":94,"name":234,"path":15,"size":235,"width":236,"height":59,"sizeInBytes":237,"provider_metadata":238},"https:\u002F\u002Fres.cloudinary.com\u002Feupry\u002Fimage\u002Fupload\u002Fv1753967295\u002Fthumbnail_Question_mark_2e23841707.jpg","thumbnail_Question_mark_2e23841707","thumbnail_Question mark.jpg",3.68,208,3680,{"public_id":233,"resource_type":62},"Question_mark_2e23841707",192.21,"https:\u002F\u002Fres.cloudinary.com\u002Feupry\u002Fimage\u002Fupload\u002Fv1753967295\u002FQuestion_mark_2e23841707.jpg",{"public_id":239,"resource_type":62},"2025-07-31T13:08:16.824Z","2026-03-26T11:07:38.872Z","mvq12t6g879c2yj2uuer89h8","2025-07-31T13:08:16.826Z",{"__component":248,"id":249,"title":157,"content":15,"blockId":250,"preTitle":15,"preTitleColor":15,"includeInGoogleSchema":13,"hideOnMobile":14,"subTitle":15,"fullWidth":15,"questions":251},"blocks.faq",2212,"faq",[252,256,260,264,268,272],{"id":253,"question":254,"answer":255},14889,"Is humidity mapping required by the FDA?","The FDA does not name it. 21 CFR 211.46(b) requires humidity control where appropriate, and facilities have been cited for not monitoring humidity.",{"id":257,"question":258,"answer":259},14890,"What is the difference between humidity mapping and monitoring?","Mapping is a point-in-time study of RH distribution across a space. Monitoring tracks RH continuously at fixed points over time.",{"id":261,"question":262,"answer":263},14891,"How many sensors do you need for humidity mapping?","It follows the same risk-based logic as temperature mapping, scaled by volume, layout, and humidity sources. There is no fixed number.",{"id":265,"question":266,"answer":267},14892,"How long should a humidity mapping study run?","Commonly 24 to 72 hours for chambers and equipment, and 7 to 10 days for warehouses, plus seasonal coverage.",{"id":269,"question":270,"answer":271},14893,"Do you need separate sensors for temperature and humidity?","No. Combined data loggers record both parameters at each point, which lets you read RH against temperature.",{"id":273,"question":274,"answer":275},14894,"Can continuous monitoring replace humidity re-mapping?","Ordinary monitoring cannot. Continuous monitoring and mapping may reduce it where data is consistent, and the rationale is documented.",{"__component":160,"id":277,"text":278,"columns":163,"title":279,"blockId":15,"hideOnMobile":14,"ulStyle":280,"ulColor":15,"withBackground":15,"buttons":281},4118,"- [Temperature mapping: tips, frameworks, and pitfalls](\u002Ftemperature-mapping\u002F)\n- [WHO temperature mapping guidelines](\u002Ftemperature-mapping\u002Fwho-mapping-guidelines\u002F)\n- [Guidelines for humidity monitoring in pharmaceutical environments](\u002Ftemperature-monitoring\u002Fhumidity-monitoring-pharma\u002F)","Related reading","checkmark",[],{"__component":30,"id":283,"title":284,"content":285,"blockId":15,"ulStyle":15,"video":15,"auto play":14,"imageLeftTextRight":14,"preTitle":15,"preTitleColor":15,"ctaInfoText":15,"titleLevel":178,"imageUrl":15,"subTitle":15,"verticalCenteredText":14,"hideOnMobile":14,"hideTopDecoration":14,"hideLastUpdated":14,"buttons":286,"media":15,"employee":15},14249,"Map both parameters in one study with Eupry","Eupry handles temperature and relative humidity in a single mapping study and carries the data through to monitoring, calibration, and audit-ready reporting – one record an inspector can follow end to end.\n\n**[See how it works →]** \u002Ftemperature-mapping\u002Four-continuous-mapping-solution\u002F  \n**[Download a catalog →]** 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